Obesity Drugs Like Ozempic Trigger Muscle Loss, But Mostly as Part of General Weight Loss

A new Annals of Internal Medicine review finds that patients on GLP-1 obesity drugs like semaglutide and tirzepatide do lose substantial muscle mass alongside fat — but researchers conclude this is likely a feature of rapid weight loss in general rather than a specific side effect of Ozempic-class drugs. The finding tempers alarmist framing while keeping clinicians attentive to resistance-training recommendations.